Pochettino’s first ever win as a manager came when Espanyol beat Pep Guardiola’s Barcelona at the Nou Camp in 2009, and the Argentinian will hope to inflict a first defeat on the Spaniard’s City this season.
Eric Dier, Mousa Dembele and Danny Rose will all be assessed by Tottenham as they near returns from hamstring injuries.
Moussa Sissoko, who suffered a head injury last weekend, may also feature, but Harry Kane is still sidelined.
Manchester City defender John Stones is likely to be recalled after dropping out of the starting line-up for Wednesday’s draw against Celtic.
Kevin de Bruyne, Vincent Kompany and Fabian Delph remain injured.
Nolito serves the final game of a three-match domestic ban.
HEAD TO HEAD
Spurs have won 22 of their 38 Premier League games against City; should they win this game, they will have beaten them more often than they’ve defeated any other side (currently tied with 22 wins v Everton).
There have been 22 goals scored in the last five Premier League meetings between these sides at White Hart Lane (9 for Spurs, 13 for Man City).
Sergio Aguero has scored 28 goals in his last 27 Premier League appearances for City.
Guardiola needs a win from this game to break the record for best winning starts to a managerial career in the Premier League (currently tied with Carlo Ancelotti on six).
This game pitches together the only two unbeaten teams left in the Premier League this season.
Four of Heung-Min Son’s eight Premier League goals have come in his last 229 minutes of action for Spurs.
MANAGERS PRESS BREIFING
Tottenham manager Mauricio Pochettino:“Maybe we are a little behind them but our expectation in the long term is to compete with all the big clubs like Manchester City, Manchester United, Liverpool.
“We are building a new stadium, we have an unbelievable training ground and we want to set the principles to be a big, big club. Our spirit and ambition is to be one of the biggest in the world, but you need time and a normal process.
“It is difficult to compare Tottenham and Manchester City. You look at their budget, the salaries they pay and compare it with Tottenham, and it is very clear… we have very different projects.”
Manchester City manager Pep Guardiola on Pochettino: “I think he’s one of the best managers in the world – I enjoy watching Tottenham.
“He’s doing an amazing job… the way they play I like a lot – they’re aggressive and have a lot of quality.
“They’re proactive, not reactive. There are many teams who wait to see what you do and then react – they [Spurs] don’t wait to see what they’re going to do. They want to create their own game. That’s why I like them.”